Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: a case report.

نویسندگان

  • Aleksandra Mamorska-Dyga
  • Jingjing Wu
  • Pallavi Khattar
  • Faisal M H Ronny
  • Humayun Islam
  • Karen Seiter
  • Delong Liu
چکیده

The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PML/RARa, could play a role in the MPN transformation to APL.

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عنوان ژورنال:
  • Stem cell investigation

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2016